The only American to win the Giro d'Italia is Andy Hampsten, who won the race in 1988 while riding for the U.S.-based 7-Eleven Hoonved team.

Stephen Roche was victorious in 1987, a year in which he also won the Tour and the UCI Road World Championship. American Andrew Hampsten became the first non-European winner the following year, and Laurent Fignon was victorious in 1989.