What casino game has the best odds? Video poker can provide the best odds in a casino, depending on the version of the paytable. However, blackjack is generally regarded as having the best casino odds when using basic strategy. This can help lower the house edge to around 0.50%.

If you're willing to put in a little work, blackjack offers the best odds. I'm talking about a . 5 percent casino edge, depending on which table you're sitting at. (Meaning for every dollar you gamble, you'll lose only half a penny on average.)